[soccertese]

http://www.labnews.co.uk/laboratory_...alt-cell-death

[Sasha]

I wonder how long this effect lasts? Any clue?

[EnglishCountryDancer]

Originally Posted by Sasha

I wonder how long this effect lasts? Any clue?

I think it was a webcast from the Young Onset Conference in 2009, which can be found on the National Parkinson's Foundation website, where there was a researcher talking about forced exercise.This took place on stationary bikes.I think he said the effects lasted for at least four months.Watch the webcast it is so interesting.

[paula_w]

I know that exercise is imperative and really helps. But most people can't run a marathon. So i take these articles much as you do soccertease about other topics, so out of reach that I can't get into them.

Exercise vigorously - and i am now through physical therapy and a new recumbent exercise bike.

it works, gives an overall guilt free feeling- not unlike that which comes over me when i use my waterpic. lol

but why are we talking about marathons? it wkrs only for a few. can't we just use the treadmill?

[la0577]

While running a marathon is not for everyone. I don't understand why the studies didn't focus on people who maintain an active lifestyle by doing things as walking, treadmill running, spinning, etc.

[GregD]

I tend to challenge the results of the studies on exercise for PD somewhat. I agree that exercise will help keep us fit and somewhat limber. However, when one exercises endorphins are released in the body. Endorphins make you feel good to the point some actually feel high as if they were taking a drug. Seems kind of funny to me that all of a sudden just because someone did a study now the #1 recommendation for PD is to exercise.

From en.wikipedia.org/wiki/Endorphin

Classically, μ opioid receptors are presynaptic, and inhibit neurotransmitter release; through this mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking this process, exogenous opioids cause inappropriate dopamine release, and lead to aberrant synaptic plasticity, which causes addiction. Opioid receptors have many other and more important roles in the brain and periphery however, modulating pain, cardiac, gastric and vascular function as well as possibly panic and satiation, and receptors are often found at postsynaptic locations as well as presynaptically.

Exercise in itself does nothing to stop or alter PD. It only tricks our bodies into a false sense of well being.
GregD

[soccertese]

Originally Posted by GregD

I tend to challenge the results of the studies on exercise for PD somewhat. I agree that exercise will help keep us fit and somewhat limber. However, when one exercises endorphins are released in the body. Endorphins make you feel good to the point some actually feel high as if they were taking a drug. Seems kind of funny to me that all of a sudden just because someone did a study now the #1 recommendation for PD is to exercise.

From en.wikipedia.org/wiki/Endorphin

Classically, μ opioid receptors are presynaptic, and inhibit neurotransmitter release; through this mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking this process, exogenous opioids cause inappropriate dopamine release, and lead to aberrant synaptic plasticity, which causes addiction. Opioid receptors have many other and more important roles in the brain and periphery however, modulating pain, cardiac, gastric and vascular function as well as possibly panic and satiation, and receptors are often found at postsynaptic locations as well as presynaptically.

Exercise in itself does nothing to stop or alter PD. It only tricks our bodies into a false sense of well being.
GregD

I think the ultimate goal is to replace the exerise with a drug(s) if they can find a cellular change.
the forced exercise researcher has a 2nd study planned with theracycle, he got a $500,000 grant. theracycle is sure hyping it imho.
there supposedly have been animal studies showing brain changes?

the researcher's is
Alberts, Jay and his article is
Forced, Not Voluntary, Exercise Improves Motor Function in Parkinson's Disease Patients

"Improvements in clinical measures of rigidity and bradykinesia and biomechanical measures of bimanual dexterity
were maintained 4 weeks after FE cessation".
study had 10 patients, 61yrs old or older.

it will be interesting to see what the 2nd study finds out.

[soccertese]

Originally Posted by la0577

While running a marathon is not for everyone. I don't understand why the studies didn't focus on people who maintain an active lifestyle by doing things as walking, treadmill running, spinning, etc.

http://www3.interscience.wiley.com/j...TRY=1&SRETRY=0

treadmill therapy

[GregD]

Originally Posted by soccertese

I think the ultimate goal is to replace the exerise with a drug(s) if they can find a cellular change.
the forced exercise researcher has a 2nd study planned with theracycle, he got a $500,000 grant. theracycle is sure hyping it imho.
there supposedly have been animal studies showing brain changes?

the researcher's is
Alberts, Jay and his article is
Forced, Not Voluntary, Exercise Improves Motor Function in Parkinson's Disease Patients

"Improvements in clinical measures of rigidity and bradykinesia and biomechanical measures of bimanual dexterity
were maintained 4 weeks after FE cessation".
study had 10 patients, 61yrs old or older.

it will be interesting to see what the 2nd study finds out.

Key words: if they can find a cellular change

[soccertese]

Originally Posted by GregD

Key words: if they can find a cellular change

article speculated gdnf or other neurotropin released which i assume has temp. benefit so no magic bullet but i'll keep an open mind.