Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 10-16-2010, 10:18 AM #1
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
Default Key to Blood-Brain Barrier and could drug Imatinib be used for this?

Key to Blood-Brain Barrier Opens Way for Treating Alzheimer’s and Stroke
ScienceDaily (Oct. 15, 2010) — While the blood-brain barrier (BBB) protects the brain from harmful chemicals occurring naturally in the blood, it also obstructs the transport of drugs to the brain. In an article in Nature scientists at the Swedish medical university Karolinska Institutet now present a potential solution to the problem. The key to the BBB is a cell-type in the blood vessel walls called pericytes, and the researchers hope that their findings will one day contribute to new therapies for diseases like Alzheimer's and stroke.


"Our new results show that the blood-brain barrier is regulated by pericytes, and can be opened in a way that allows the passage of molecules of different sizes while keeping the brain's basic functions operating properly," says Christer Betsholtz...

"Another interesting find is that the cancer drug Imatinib, which
inhibits certain signal proteins for cell growth, has a similar effect
in the presence of pericytes in that they also close the capillary
wall transport paths," says Professor Christer Betsholtz.
http://www.sciencedaily.com/releases...1014083341.htm
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here — it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote

advertisement
Old 10-16-2010, 10:44 AM #2
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
Default another use for Imatinib and PD?

(all this seems interesting though not applicable at present to me. Have noticed the term "NGF dysfunction ": seems nerve growth dysfunction is the newest "dysfunction theory" in PD. recent reports on DJ1[PARk7] and PD)

http://www.sciencedaily.com/releases...1001163342.htm


Parkinson's: Excess of Protein Suggests New Target for Treatment With
Widely Used Anti-Cancer Drug Imatinib


ScienceDaily (Oct. 4, 2010) ‹ Johns Hopkins scientists have discovered
that the over-activation of a single protein may shut down the
brain-protecting effects of a molecule and facilitate the most common
form of Parkinson's disease...

Previous research demonstrated that a protein called parkin protects
brain cells by "tagging" certain toxic elements that are then destroyed
naturally. It was also known that mutations in the gene that holds the
code for parkin cause rare, familial forms of PD. However, parkin's role
remained unclear in sporadic late-onset PD, the prevalence of which is
increasing as the population ages...
...Results of the new study, published Sept. 7 in the Proceedings of the
National Academy of Sciences (PNAS) Online Early Edition, indicate that
an over-activation of a protein called c-Abl- can shut down the activity
of parkin and contribute to a build-up of toxic proteins that kill brain
cells and enables the progression of PD.


C-Abl contributes to the regulation of cell death and is implicated in a
host of diseases. It has already has proven to be a target for certain
types of cancer-killing drugs, such as imatinib (Gleevec), the first
drug designed to directly switch off a biochemical signal that directly
targets a protein vital to cancer growth, says Ted Dawson, M.D., Ph.D...
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here — it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Blood-Brain Barrier Ronhutton Parkinson's Disease 3 02-02-2010 02:30 PM
Blood Brain Barrier in ALS Ronhutton ALS 2 08-12-2008 05:54 PM
Blood Brain Barrier Ronhutton Parkinson's Disease 43 05-24-2008 05:36 AM
Blood Brain Barrier Ronhutton Multiple Sclerosis 9 03-07-2007 02:56 PM
The Blood Brain Barrier Ronhutton Parkinson's Disease 21 09-05-2006 03:46 PM


All times are GMT -5. The time now is 08:25 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.