[smik85]

My mom is 74 and has had pd for 22 years. In August we took her off mirapex and started her on Azilect. It has been un uphill battle. She is also on sinemet controlled release, and quick release and exelon for her memory and dementia.
Has anyone had difficulty with Azilect or Exelon?

[rd42]

I may be in a different boat, I'm 31 and on .5mg/day of Azilect and have been for 28 days.

My mood has been a little better since the Azilect but my symptoms haven't changed, I might even say they are a little worse.

Here is another link in the forum talking about Azilect:
http://neurotalk.psychcentral.com/sh...hlight=azilect

Good luck and thanks for helping some one with PD.

Robert

[maryfrances]

Robert,

How is it going w/the azilect? What kind of differences are you noticing with it?

Mary

[Slumpy]

Mary,
I've been on azilect as a monotherapy as part of a 3 month Phase III trial being managed by my neuro at Scripps La Jolla (San Diego), CA. I was diagnosed on 19 Dec 06 but as almost everyone, I've had symptoms for almost 2 yrs.

I had my third weekly follow-up with my neuro as part of the trial on 19 Feb, after 25 days in the trial (first 7 days @ .5MG then 1MG since). On 19th I was very disappointed...I had some minor improvements but nothing like I expected. But...my neuro felt that he was seeing improvement and my scores were better. Then within a few days of my appt I finally started feeling more improvement---less active tremor (jerkiness), little better movement and less stiffness in my right arm and neck. I did degrade a little over the weekend but I'm blaming that on too much wine and margaritas while spending the weekend in my motorhome at the NASCAR race at CA Speedway But I'm definately doing and feeling better just not as good as I expected but maybe my expectations are too high.

The neuro, a movement disorder specialist who lectures at UC San Diego and is the medical advisor for the San Diego PD Assoc, wants to give it more time and finish the 3 month trial. My next and final appt in the trial 19 April with a interim phone follow-up in 1 month.

Slumpy

[maryfrances]

Thanks, Slumpy-

Good info. I am on .5 mirapex 3X a day and .5 azilect once a day. Azilect was just added, but seems to make tremor worse. I had high hopes for it, too, but am disappointed. I have been diagnosed a year and a half. You sound like you have a good doctor. Not many in my area. Let me know how it goes for you.

LOL
Mary

[Perryc]

Hi Mary and everyone else,

I have been taking Azilect for about 8 months (since the first week it was released). I take 1mg once per day (which is much easier to remember than my sinemet and comtan @ 6-7 times per day. and I have had a very good response so far. I had stopped mirapex a year prior, so at that time my sinemet was up to 1700-1800 mg levodopa even with comtan 50/250 7 or more times daily, which I think was too much sinemet and I was beginning to get dyskinesias for the first time after 10 years diagnosed. Graduallly since I have began with Azilect my offs are shorter and less severe and reduced by half. I have reduced the sinemet/ comtan by stretching the the time from 2:15 min between doses and cutting the doses to 2x 25/100 Sinemet plus comtan and co-q10 now 6 times daily (1200 mg). Now I have been getting more dyskinetic so I am trying to cut down further on sinemet. I havent noticed side effects except increased dyskinesias. At 11 yr since dx I am mid stage PD but still sinking. I have heard of early stage Pwp with good results also.

I have known the director of neuro research from Teva for several years (who lead the clinical research on Azilect for FDA approval, and I met the director of the rasagiline program in Teva from Israel last week at a meeting in DC.. As far as pharmaceuticals go it is a good company.

Perry

[rd42]

I've been on Azilect for 38 days, 1\mg\day for the past 10days. If anything, my symptoms have progressed to my right side. My state of mind has impoved may a tiny bit and I don't seem to be having any side effects.

This disease sucks. I want a new disease, one that make you happier and healthier than normal, and it would have to be contagious

Robert

[maryfrances]

Thanks Perry

------------------------

I'm with you, Robert. This disease does suck. What'd I ever do to deserve this?? I want a new disease, too. I'm too young for this one and I know that you are!



Mary frances

[mylife40]

When I first started taking 1 - 5mg a day I felt worse , then I split it in half with each of my 1st and 2nd doses of meds of the day. I found that my stiffness, shaking was gone . So you may want to consider biting your pill in half.

[JS82]

Robert,

How did Azliect turn out for you? Did you stay with it?

I've been switched from Sinemet + Mirapex to + Sinemet + Azilect +Comtan.
What do you all think?

John