[reverett123]

1. Gerontology. 1987;33(3-4):168-71.

Dopamine action and disorders of neurotransmitter balance.

Birkmayer W, Birkmayer JD.

Evangelic Hospital, Vienna, Austria.

Disorders of neurotransmitter balance are observed in Parkinson's disease,
pharmacotoxic psychosis and depression. The dopamine-serotonin ratio is reduced
to about 20% in Parkinson and pharmacotoxic patients in the caudate nucleus and
in the substantia nigra. The serotonin content in these brain areas is lowered
only to about 50% in comparison to that of the control, whereas the dopamine
level is reduced to 85% in Parkinson patients. This dopamine deficiency has been
substituted by exogenous supply of L-dopa in combination with decarboxylase and
monoaminooxydase inhibitors. First evidence is presented that L-dopa can be
replaced, at least partially, by iron in form of a ferriascorbate complex. This
iron compound improves the symptoms of Parkinson's disease to almost the same
extent as L-dopa.

PMID: 3653699 [PubMed - indexed for MEDLINE]

The Birkmayers were once big names in PD research. Here they report that iron is as good as Ldopa. When we ask about iron we get vague warnings and little more. Anyone know more on this?

[reverett123]

I just realized that I had posted on this about three weeks ago but rather than erase it, I think it needs attention.
The Birkmayers (W & JD) were German. I suspect that W was father and JD son because W has 172 papers to his credit at PubMed. JD has just two - the one you read here and a companion one published the same year. W , with his 172 papers, built up a larger body of work. But these two papers were numbers 162 and 163. His career was just about over, whether he knew it or not.

So what happened to the Birkmeyers?

[moondaughter]

Originally Posted by reverett123

I just realized that I had posted on this about three weeks ago but rather than erase it, I think it needs attention.
The Birkmayers (W & JD) were German. I suspect that W was father and JD son because W has 172 papers to his credit at PubMed. JD has just two - the one you read here and a companion one published the same year. W , with his 172 papers, built up a larger body of work. But these two papers were numbers 162 and 163. His career was just about over, whether he knew it or not.

So what happened to the Birkmeyers?

I spoke with Dr. Birkmeyer on the phone in '94. He told me CAT scans were pointless (unless I was having headaches or other unique sx diff than pd sx)and that I should take NADH (i think he had the patent or had s ome interest in NADH). it was a very short conversation!

md

[imark3000]

http://www.webs.uidaho.edu/wisui/Kau...lar%20Iron.pdf

I didn't have the stamina to read the above long article which may shed light on the subject.

Interestingly, my blood test done after starting sinemet showed deficiency in iron and my family doctor perscribed iron tablets which I took for one month.

I always assumed that iron increases oxidative stress. but I realise now that iron is vital and it is delicately kept in balance by the cell.

Imad

[Ronhutton]

Hi Rick,
We PDers have abnormal iron levels, abnomally high that is, up to 7 times normal. iron is a powerful oxidation catalyst, so it seems not a good idea to add more.See

http://www.sciencedaily.com/releases...0610081311.htm
Science News Share Blog Cite Print Bookmark Email
Parkinson's Disease Linked To High Iron Intake
ScienceDaily (June 10, 2003) — ST. PAUL, MN – People with high levels of iron in their diet are more likely to develop Parkinson's disease, according to a study in the June 10 issue of Neurology,


http://www.physorg.com/news169899879.html
Parkinson's disease: Iron accumulation to the point of demise


Multiple studies implicate iron in the pathophysiology of Parkinson's disease (PD). In the brains of patients with PD, iron levels are elevated and the levels of iron-binding proteins are abnormal. Iron has been suspected to contribute to PD because Fe(II) is known to promote oxidative damage. Recent studies suggest that an additional mechanism by which iron might contribute to PD is by inducing aggregation of the alpha-synuclein, which is a protein that accumulates in Lewy bodies in PD.

PMID: 11843096 [PubMed - indexed for MEDLINE]

Might be an idea to contact the Birkmeyers if they are still around.

Ron

[reverett123]

1. Int J Alzheimers Dis. 2010 Dec 27;2011:720658.

Iron and mechanisms of neurotoxicity.

Salvador GA, Uranga RM, Giusto NM.

Instituto de Investigaciones Bioquímicas Bahía Blanca, Universidad Nacional del
Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, 8000 Bahía
Blanca, Argentina.

The accumulation of transition metals (e.g., copper, zinc, and iron) and the
dysregulation of their metabolism are a hallmark in the pathogenesis of several
neurodegenerative diseases. This paper will be focused on the mechanism of
neurotoxicity mediated by iron. This metal progressively accumulates in the brain
both during normal aging and neurodegenerative processes. High iron
concentrations in the brain have been consistently observed in Alzheimer's (AD)
and Parkinson's (PD) diseases. In this connection, metalloneurobiology has become
extremely important in establishing the role of iron in the onset and progression
of neurodegenerative diseases. Neurons have developed several protective
mechanisms against oxidative stress, among them, the activation of cellular
signaling pathways. The final response will depend on the identity, intensity,
and persistence of the oxidative insult. The characterization of the mechanisms
mediating the effects of iron-induced increase in neuronal dysfunction and death
is central to understanding the pathology of a number of neurodegenerative
disorders.


PMCID: PMC3014724
PMID: 21234369 [PubMed - in process]

[moondaughter]

Interesting thread - I was dx as anemic as a young child and was given desicated liver pills. Is anemmia a common pattern inearly onsetttters?

I would suspect I should eat liver as a dietary regimen but what kind?

I have a repetitive dream of getting trapped at the iron works steel mill plant in the town where I grrew up in.

md

[reverett123]

Moondaughter mentions anemia. I, too, had a strange anemia about thirty years ago. It was not one of the common names and I don't remember much except that my GP was *very* concerned. I had eliminated red meat from my diet and reintroducing it cured the problem. I don't recall any mention of anemia being a risk factor for PD, but who knows.

One thing I have been thinking about is cast iron cookware. It is a significant source of iron in the diet and if one cooked acidic foods such as tomatoes then you should be approximating "ferric ascorbate". I remain convinced that PD came with the Industrial Revolution, but cast iron pots existed well before then. There should be a direct tie between their use and PD, I think.

But is there?

[Ronhutton]

Rick,
I see no reason why both our stories could be right. The iron complex of the Birkmayers could act as a chemical messenger, then end up in a ferritin molecule in the PDers iron store, where it can promote oxidation and undo the good that it has just done. After all, once it has done its good work, it has to go somewhere.
Perhaps we could still use the chemical messenger ptoperties of the iron complex, in conjunction with a chelator to remove the excess iron??
Fortunately iron can be chelated out.
Ron

[reverett123]

Good point Ron.
I wonder, too, if there is any link between a society's use of iron or steel cookware and PD. You may remember claims that red meat (high iron) might be a risk factor. I wonder how beef consumption would plot against PD. India, being low in both, is an obvious one. The US and England are at the other extreme, also in both.