Parkinson's Disease Tulip


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Old 06-21-2008, 09:55 AM #1
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Default GDNF importance in transplanted mouse tissue dopamine neuron viability

(still wondering about the utility of Ibocaine)
http://www.intr10.org/2008/06/20/19-06-08160645/
19-06-08(16:06:45)
Authors:

Nevalainen N, Rehnmark A, Marschinke F, Berglöf E, and Strömberg I
Department of Intregrative Medical Biology, Umeå University, Sweden


Title of abstract : Nigrostriatal cografts degenerate when deprived of glial cell line-derived neurotrophic factor (GDNF)

Abstract text:

Glial cell line-derived neurotrophic factor (GDNF) has promoting effects on ventral mesencephalic (VM) dopamine neurons in terms of cell survival and nerve fiber outgrowth. In the present study the effects of GDNF on developing dopamine neurons were studied by transplanting mouse fetal tissue into the lateral ventricles of adult mice. VM and lateral ganglionic eminence (LGE) were obtained from E14 fetuses with different gdnf genotypes i.e. fetuses being wildtype, heterozygous or knockout. Transplants were left to develop in the lateral ventricles of adult wildtype mice and evaluated after 6 months for surviving dopamine neurons, as revealed by immunohistochemistry against tyrosine hydroxylase (TH). When evaluated, it was observed that in transplants from gdnf knockout tissue significantly fewer TH-positive neurons survived compared to wildtype grafts. Interestingly, in grafts derived from gdnf gene deleted tissue, poor survival of both VM and LGE was found at 6 months. Furthermore, the pattern of dopamine nerve fiber innervation in LGE appeared to be different when comparing heterozygous and wildtype tissue. Whereas in wildtype tissue dopamine-rich islands were seen, the innervation was sparse and less dense in heterozygous tissue. The results of this study indicate that GDNF is an essential neurotrophic factor when it comes to long-term dopamine cell survival and proper innervation of the striatum.
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