[olsen]

http://www.jneurosci.org/cgi/content...ct/28/50/13609
Negative Impact of Statins on Oligodendrocytes and Myelin Formation In Vitro and In Vivo

Steve Klopfleisch,1 * Doron Merkler,2 * Matthias Schmitz,1 Sabine Klöppner,1 Mariann Schedensack,2 Gunnar Jeserich,4 Hans H. Althaus,1 and Wolfgang Brück2

Statins are widely prescribed drugs in cardiovascular diseases. Recent studies also demonstrated anti-inflammatory and immunomodulatory properties of statins by modulating the activity of small GTPases. Statins are thus considered as potential therapeutic drug for the inflammatory demyelinating disease multiple sclerosis (MS). However, little is known about the effects of statins on myelin-forming oligodendrocytes. Here, we show that statins hamper process and myelin formation in vitro by interfering with Ras and Rho signaling in mature oligodendrocytes and provide evidence that statins impair ongoing remyelination in vivo. Our findings may have significant implications for the application of statins in MS patients and in other demyelinating diseases of the CNS.

[SallyC]

I don't know why, maybe a sixth sense, but I never considered, seriously, taking Statins for MS. Too many side effects and, of course, the danger of the drug, itself.

Thanks for the info.