Parkinson's Disease Tulip


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Old 07-13-2009, 03:56 AM #1
aftermathman aftermathman is offline
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aftermathman aftermathman is offline
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Join Date: Sep 2006
Location: Evesham, England
Posts: 598
15 yr Member
Default Oxford Biomedica Update On Phase I/II Study Of ProSavin®

Oxford Biomedica are in clinical trials with Prosavin, a gene therapy product for PD, details in this link:

http://www.oxfordbiomedica.co.uk/page.asp?pageid=17

"Patients treated at the first dose level have maintained their improvement in motor function for one year, with an average improvement of 29%. Analogous investigator assessments of patients in the second cohort treated at a higher dose level have achieved similar benefit at three months, and the first patient to reach their six-month assessment has demonstrated further improvement".

"ProSavin has been safe and well tolerated in all patients, with no serious adverse events and no evidence of immunotoxicity. All patients have reduced or maintained their PD medication relative to baseline".

"One year after their treatment, patients at the 1x dose have maintained their improved motor function with an average increase of 29%. All patients have enhanced their quality of life, based on a standard measure of clinical benefit that is recorded by the patient using a questionnaire known as PDQ-39. The average increase in patients’ PDQ-39 score was 42% at one year".

At three months, patients at the 2x dose have increased motor function with an average improvement of 28% and the first of these patients to be assessed at six months has shown further benefit. All patients in the second cohort have experienced a better quality of life at three months with an average improvement of 33%.

See this link for full report.

http://www.oxfordbiomedica.co.uk/pag...=59&newsid=236

Neil.
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