[Ronhutton]

Has anyone any experience of the above? Girija, what do you think?
See
http://www.marshallprotocol.com/forum46/7287.html

where it describes the MP as

"The Marshall Protocol is a medical treatment being used by physicians worldwide to treat a variety of chronic inflammatory and autoimmune diseases including (but not limited to) sarcoidosis, Chronic Fatigue Syndrome, fibromyalgia, Crohn’s Disease, and rheumatoid arthritis. While other treatments for chronic disease use palliative medications in an effort to cover up symptoms, the Marshall Protocol is a curative treatment, which strives to address the root cause of the disease process.

Information about the treatment can be found at the study site, marshallprotocol.com and also at autoimmunityresearch.org. The site is run by the staff of the Autoimmunity Research Foundation, a California-based non-profit agency. Over 200 health professionals are members of the site, and discussions are moderated by a group of volunteer nurses. There is no charge to use the website or the treatment and all patients are welcome to participate.

The Marshall Protocol is a phase II community-based internet study that is monitored by the FDA. The FDA has already granted orphan product designations for two of Autoimmunity Research Foundation’s six applications – Sarcoidosis, and Post Treatment Lyme Disease Syndrome (PTLDS, commonly known as chronic Lyme). The Foundation continues to work with the FDA to make effective therapies available in an even wider array of chronic diagnoses."

The MP seems to work by retricting the level of vitamin D in the body. The site also says,

"The ability of the Th1 pathogens to proliferate in the body is directly related to the vitamin D receptor (VDR). Critically important to the body, the Vitamin D Receptor (VDR) controls the innate immune system – the body’s first line of defense against infection. It’s also responsible for turning on/off a wide array of genes and chemical pathways. One of the VDR’s myriad jobs is to control expression of several families of antimicrobial peptides (AMPs), proteins that kill bacteria, viruses and fungi by a variety of mechanisms including disrupting membranes, interfering with metabolism, and targeting components of the machinery inside the cell.

Although casually referred to as a vitamin by some members of the medical community, molecular biologists have long realized that the precursor form of vitamin D (25-D) is really a secosteroid. Recent molecular modeling research (which has been confirmed by a large amount of clinical data) has shown that levels of 25-D over 20 ng/ml can bind and inactivate the VDR, which subsequently shuts down the innate immune system"

A Google on the Marshall Protocol gives over half a million hits, yet I have never heard of it up to now. There is a forum site with over 20 pages of success stories in chronic diseases.

Ron

"

[reverett123]

Ron-
I have heard of this for some time and I suspect there may be something to it. Unfortunately it is a longterm treatment and, also, the researcher doesn't fit into the system and gets dissed. The Naturopath I used to see when I could afford him thought well of the work.

I will point out that Vitamin D has been showing more importance lately. It might give some clues to know who claimed what first.

[RLSmi]

Ron and Rick,
I have also read quite a bit about the Marshall Protocol. It seems that the question about vitamin D is "too little, or too much?". What I read concerning the MP involved an initial treatment in which Vitamin D, including that generated in skin by sunlight, is stringently restricted. Other, subsequent stages of the treatment involve the use of certain antibiotics.

What is strange is that the "experts" in vitamin D function are now suggesting that the current recommended daily allowance, or RDA, for D is much too low. The other day I heard someone on a medical program say that a minimum of 1000 units/day should provided for a normal adult, but twice that amount was now recommended. Previously, the recommended daily value was less than 500 units.

The one attractive feature of the MP is that it appears to focus on chronic inflammation resulting from inappropriate stimulation of the innate immune system by the notorious "Th1 pathogens".

[reverett123]

<snippets>
The MP seems to work by retricting the level of vitamin D in the body.

levels of 25-D over 20 ng/ml can bind and inactivate the VDR, which subsequently shuts down the innate immune system"
<end>

If I understand this right, the MP restricts Vit D. The result would be continued activity of the innate immune system.

Since the big problem in PD seems to be an overactive innate system, it would seem counter-intuitive (i.e. "dumb" ) to promote "continued activity".

The opposite would be true if one were after a hidden pathogen, which is what I remember the MP being about. And it may be just dandy for that. But for auto-immunity something doesn't fit.

[kenki]

I asked my specialist in Chronic Fatigue syndrome to comment on Marshal Plan claims that extra supplementation of Vitamin D results in shutting down the immune system altogether.

She replied as follows:

“I am familiar with the MP but I still don’t buy it! They talk about 25 D. This is not cholecalciferol – it is what the body chooses to make from CC. So unless there is overt deficiency of CC, it is a case of regulation – and I doubt that will happen simply through diet.

CC has so many important functions I cannot believe it is desirable to inhibit syntheses of 1CC and 1:25 DHCC by restricting sunshine and diet!

It’s all about the dose. In UK we are all deficient because of lack of sunshine. In Africa normal levels run at 100-150 – in UK normal range is said to be 20-70! My aim is to get levels up to the evolutionary correct levels.

It is highly protective against Swine flu”

She also attached an abstract from a research paper on Vitamin D:

Vitamin D is really important!
Skin contains a Cholesterol derivative, 7-dehydrocholesterol. UVB radiation on skin breaks open one of the carbon rings in this molecule to form vitamin D. The activated form of vitamin D (1,25-dihydroxyvitamin D) attaches to receptors on genes that control their expression, which turn protein production on or off. Vitamin D regulates the expression of more than 1,000 genes throughout the body. They include ones in macrophages, cells in the immune system that, among other things, attack and destroy viruses. Vitamin D switches on genes in macrophages that make antimicrobial peptides, antibiotics the body produces. Like antibiotics, these peptides attack and destroy bacteria; but unlike antibiotics, they also attack and destroy viruses.
Vitamin D also expresses genes that stop macrophages from overreacting to an infection and releasing too many inflammatory agents - cytokines - that can damage infected tissue. Vitamin D, for example, down regulates genes that produce interleukin-2 and interferon gamma, two cytokines that prime macrophages and cytotoxic T cells to attack the body's tissues. In the 1918-19 Spanish flu pandemic that killed 500,000 Americans, young healthy adults would wake up in the morning feeling well, start drowning in their own inflammation as the day wore on, and be dead by midnight. Autopsies showed complete destruction of the epithelial cells lining the respiratory tract resulting, researchers now know, from a macrophage-induced severe inflammatory reaction to the virus. In a terribly misguided way, these victims' own immune system attacked and killed them, not the virus, something in future pandemics vitamin D, in appropriate doses, can prevent.
A creditable hypothesis that explains the seasonal nature of flu is that influenza is a vitamin D deficiency disease. Cannell and colleagues offer this hypothesis in "Epidemic Influenza and Vitamin D" (Epidemiol Infect 2006;134:1129-40). They quote Hippocrates (circa 400 B.C.), who said, "Whoever wishes to investigate medicine properly should proceed thus: in the first place to consider the seasons of the year." Vitamin D levels in the blood fall to their lowest point during flu seasons. Unable to be protected by the body's own antibiotics (antimicrobial peptides) that this gene-expresser engineers, a person with a low vitamin D blood level is more vulnerable to contracting colds, influenza, and other respiratory infections (e.g., respiratory syncytial virus).
Studies show that children with rickets, a vitamin D-deficient skeletal disorder, suffer from frequent respiratory infections; and children exposed to sunlight are less likely to get a cold. Given vitamin D's wide-ranging effects on gene expression, other studies, for example, show that people diagnosed with cancer in the summer have an improved survival compared with those diagnosed in the winter (Int J Cancer 2006;119:1530-36)”I am not a scientist and could not comment. Is this useful?

Kenki

Originally Posted by reverett123

<snippets>
The MP seems to work by retricting the level of vitamin D in the body.

levels of 25-D over 20 ng/ml can bind and inactivate the VDR, which subsequently shuts down the innate immune system"
<end>

If I understand this right, the MP restricts Vit D. The result would be continued activity of the innate immune system.

Since the big problem in PD seems to be an overactive innate system, it would seem counter-intuitive (i.e. "dumb" ) to promote "continued activity".

The opposite would be true if one were after a hidden pathogen, which is what I remember the MP being about. And it may be just dandy for that. But for auto-immunity something doesn't fit.

[girija]

Ron,
I just read this post. I do not know much about MP.If it deals with inflammation, it is of interest to me and I will try to get more info

thanks
girija

[seanlane]

Having had "incurable" neuropathy and see it disappear along with numerous other chronic conditions...I can say first hand the Marshall Protocol is valid...I believe it will become the model to follow in treatment of many different types of diseases caused by intra-phagocytic microbiota.Yes...you can dampen the infected and dysfunctional immune system and 'escape' the cytokine storm caused by stimuli such as a virus.....but the big elephant in the middle of the room is l-form bacteria that form biofilms and evade the immune system. Beta-lactam anti-biotics promote these l-forms by attacking their wall,some of the bacteria simply survive as cell wall deficient forms[l-forms]
They can only be studied in-vivo. It[the Marshall Protocol] is alot like the science that revealed that the earth is round, it will take some time before the paradyme changes. Medicine is so interpretive,and that's the only way it could be until now. Marshall Protocol comes more from an engineering and molecular modeling standpoint that is really more defined as definitive science.
It is not an easy treatment....as soon as you take the subinhibitory doses of minocycline,azithromycin,and clindamycin in a pulsed dose fashion along with a VDR agonist....{none of which have side-effects in healthy people}...you clearly feel the resulting herxiemer reactions.....and you know 25 milligrams of minocycline could not have produced such a reaction.......it's the little bugs...they start having their ribosome production shut down...and the immune system starts to kill what should have never been there. Meanwhile the VDR agonist allows the body"s own antimicrobial peptides to return to production[there are thousands of these]

Originally Posted by kenki

I asked my specialist in Chronic Fatigue syndrome to comment on Marshal Plan claims that extra supplementation of Vitamin D results in shutting down the immune system altogether.

She replied as follows:

“I am familiar with the MP but I still don’t buy it! They talk about 25 D. This is not cholecalciferol – it is what the body chooses to make from CC. So unless there is overt deficiency of CC, it is a case of regulation – and I doubt that will happen simply through diet.

CC has so many important functions I cannot believe it is desirable to inhibit syntheses of 1CC and 1:25 DHCC by restricting sunshine and diet!

It’s all about the dose. In UK we are all deficient because of lack of sunshine. In Africa normal levels run at 100-150 – in UK normal range is said to be 20-70! My aim is to get levels up to the evolutionary correct levels.

It is highly protective against Swine flu”

She also attached an abstract from a research paper on Vitamin D:

Vitamin D is really important!
Skin contains a Cholesterol derivative, 7-dehydrocholesterol. UVB radiation on skin breaks open one of the carbon rings in this molecule to form vitamin D. The activated form of vitamin D (1,25-dihydroxyvitamin D) attaches to receptors on genes that control their expression, which turn protein production on or off. Vitamin D regulates the expression of more than 1,000 genes throughout the body. They include ones in macrophages, cells in the immune system that, among other things, attack and destroy viruses. Vitamin D switches on genes in macrophages that make antimicrobial peptides, antibiotics the body produces. Like antibiotics, these peptides attack and destroy bacteria; but unlike antibiotics, they also attack and destroy viruses.
Vitamin D also expresses genes that stop macrophages from overreacting to an infection and releasing too many inflammatory agents - cytokines - that can damage infected tissue. Vitamin D, for example, down regulates genes that produce interleukin-2 and interferon gamma, two cytokines that prime macrophages and cytotoxic T cells to attack the body's tissues. In the 1918-19 Spanish flu pandemic that killed 500,000 Americans, young healthy adults would wake up in the morning feeling well, start drowning in their own inflammation as the day wore on, and be dead by midnight. Autopsies showed complete destruction of the epithelial cells lining the respiratory tract resulting, researchers now know, from a macrophage-induced severe inflammatory reaction to the virus. In a terribly misguided way, these victims' own immune system attacked and killed them, not the virus, something in future pandemics vitamin D, in appropriate doses, can prevent.
A creditable hypothesis that explains the seasonal nature of flu is that influenza is a vitamin D deficiency disease. Cannell and colleagues offer this hypothesis in "Epidemic Influenza and Vitamin D" (Epidemiol Infect 2006;134:1129-40). They quote Hippocrates (circa 400 B.C.), who said, "Whoever wishes to investigate medicine properly should proceed thus: in the first place to consider the seasons of the year." Vitamin D levels in the blood fall to their lowest point during flu seasons. Unable to be protected by the body's own antibiotics (antimicrobial peptides) that this gene-expresser engineers, a person with a low vitamin D blood level is more vulnerable to contracting colds, influenza, and other respiratory infections (e.g., respiratory syncytial virus).
Studies show that children with rickets, a vitamin D-deficient skeletal disorder, suffer from frequent respiratory infections; and children exposed to sunlight are less likely to get a cold. Given vitamin D's wide-ranging effects on gene expression, other studies, for example, show that people diagnosed with cancer in the summer have an improved survival compared with those diagnosed in the winter (Int J Cancer 2006;119:1530-36)”I am not a scientist and could not comment. Is this useful?

Kenki

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