I found an interesting article about a company that claims to found an agent (LMTX) holding progression of Alzheimer with 90 % !!! This impressive number results from a 2 year clinical phase II study. They are testing it now in a phase III for people with Pick's disease. In the end of the article they say there is proof LMTX also removes other proteins bad for the brain, like asyn in PD !!!

Interestingly, the drugs in development are improved versions of methylene blue, discussed previously in this forum.

"TauRx’s pipeline of therapeutics includes a range of compounds that have arisen from research, preclinical and clinical investigations the Company first performed using rember™. rember™ is TauRx’s ultrapure Tau Aggregation Inhibitor (TAI), with patents pending, a version of methylene blue (methylthionine chloride), a comparatively crude and poorly tolerated compound previously used to treat a variety of conditions. TauRx has discovered and is developing alternative forms of the same active moiety present in rember™ that have been chemically optimized to afford enhanced tolerability and bioavailability, enabling their use at higher doses than rember™. TauRx’s TAIs are backed by a robust patent estate.


TauRx’s lead “second generation” TAI has the potential to achieve greater clinical efficacy than the striking effects already shown with rember™. Delivering the same active moiety in the blood as rember™, the clinical tolerability profile of LMTX, one of TauRx’s second generation TAIs, is currently being investigated clinically in trials conducted under an open US IND. TauRx is now preparing to advance LMTX into pivotal international phase 3 trials in mild and moderate AD and related neurodegenerative diseases."

You may remember the somewhat bewildering press releases and reports about the miracle of the Blue. But it quickly was contained with talk of swimming pool-sized volumes and no one seemed to know any approximate dosages and everyone in a position to know kept their mouth tightly shut.

Now comes this disgusting pig swallop and reading between the lines tells us a great deal. For example-


Translation- We've been feeding our attornys raw meat while we figured out how to get a patent on this cheap stuff so you had better stay away from our fish tank if you don't want to get hurt!!!

Folks, this is one of the most exciting things to come along since my diagnosis. These guys are sitting on a volcano and they know it! You can almost see the sweat roling off their brow as they try to beat the competition. Pass the fish sauce, my friends. We just may have lived long enough to see the Cure.

Reverette are you being facetious or do you mean this has potential?

I spoke with one of the lead folks in Texas working with a methylene blue derivative...they have applied for a patent on it, I assume through the university/college they are working and doing the research through. He was very generous with his time and expertise, and I was surprised to hear him say he believed, as many here do, that PD may have multiple causes.

While he could not, and would not, tell me how much one could/should take, I did get from our conversation that we would be wise to try it. I told him we were going to try it anyway and white rat it ourselves, I was just calling him to see what the next step for their research lab was and how long they expected things to take....he understands time is of the essence no matter what "stage" someone is at because PD sucks at every stage.

Now, we did buy a big vat of methylene blue (DON'T get it from a pet store, please!) and started taking an amount that we could garner from various sites here and there....but I think it was too much as it caused stomach pain, probably killing off the good bacteria along with the bad. We need to dilute the concentration and try again...will report as we know more.

I just wanted to chime in that we had spoken with one of the researchers about this and it sounded quite positive.

I am quite serious. A little loopy from the day's Ldopa perhaps, but serious none-the-less. From the moment that Dr. Bruce Ames, a very respected researcher, and team announced this things have been very unusual. Downright odd, in fact. Google it and see what I mean. A bright spark lasting just a few days, followed by silence. Nothing for three or four years. Then suddenly this pops up. And, as best I can tell, they aren't asking for money, either.

Also, it seems to me that they went from the weird discovery stage to advanced clinical trials awfully darned quick. But how do you do that and why? One possible answer is to go after some closely related disease that is wide open because nobody has it so there is little competition. Get your patents and approvals. Put it on the pharmacy shelf and bring up the off-label possibilities.

http://www.fiercebiotech.com/press-r...-alzheimers-di


that alzheimer phase2 trial was reported in 2008, there appears to be no phase3 trial.

discussion of phase2 trial
http://www.alzforum.org/new/detail.asp?id=2203#{900222A1-1421-48BD-ABD6-0FE5CA664F88}
from this discussion not sure if they even published their results in a peer reviewed journal.

http://www.alzheimersreadingroom.com...rapeutics.html

http://www.taurx.com/resources_pub.htm

i'd be very careful taking methylene blue

my apologies if i missed something.

Thanks for the links.

The Fierce Biotech article (dated ?) calls phase III imminent and says if confirmatory, the drug would be produced starting 2012. But then the Alzheimer's Reading Room link says it never went to phase III , without elaborating. Could it have gone to to Phase III and just not been made public or are there public disclosure requirements that pertain to drug trials?

No, not loopy at all--just way above my head!

heres another article date aug, 2008 so fierce article describing same event.
no phase3 results on their website and no published peer reviewed phase 2 results that i can find.
http://www.taurx.com/news.htm