My brother, please tell me how you incorporate Mucuna into your daily routine.
At 8 years you have alot of experience with Mucuna.

Well friend ill tell you this ....I take it PRN only....per required need.....I start out with it in the am for sure to get my lungs going....about 300 mg standardized or on a bad day up to 1200mg standardized.......I take it before I cut trees, or deep sea fish, or hunt etc as a preventive....and I take high doses when I cant breath for example....as high as 5000 mg or more even....there is a lot of things pd does to me and I don't claim to have a cure, reversal, etc......but I believe I'm slowing down the neurodegeneration.....and I don't believe in the effectiveness in allopathic medicine. I'm in control.....and I love practicing PD alchemy.....for example has anyone ever thought to take 1 dose natural mucuna with a regular sinemet to take advantage of the Carbidopa present in the heromet to allow even more L-dopa across the BBB? this can essentially cut your heromet use in half and replace half with natural L-dopa.......just a thought for you.....


peace!

BP

Hello, I found this thread while looking up info on the amino therapy program. My husband had been using the program for depression/anxiety NOT Parkinson's, but it's the same program, just modified a bit. He was seeing some changes by the third month but just couldn't take the nausea from the l-cysteine anymore and so stopped. This has been the only thing that has ever helped and so I've been trying to find a way to deal with the nausea. The doctor we were dealing with didn't have any suggestions except "it will pass" or to come up more slowly, which didn't work either. Have any of you on the program dealt with nausea and how did you resolve it? Thanks!

Hello! I never get ill from A-L-Cysteine but I buy it in bulk and mix it in with my morning veg/nute blender mixture....perhaps take it with food?

peace

BP

At what times was he taking the L-Cysteine? 20% of patients experience GI upset if they take the CysReplete in the morning thus it is advised to not take the CysReplete until the 2nd dosage of the day at noon, then 4 pm, then 7 pm. So if he was taking it with the first dosage in the morning you could try waiting to start taking the CysReplete until the 2nd dosage of the day.

What is the total amount of amino acids he was on? Since he has depression and anxiety it is likely that to achieve optimal results changes in dosage are done by doing lab tests. Is this the case? Or was he found to be dopamine dominant? I'm just wondering if you are certain that the nausea is from the Cysteine and not from him taking a substantial amount of L-dopa.

Thank you for the replies! On our own, we tried both with and without food and shifting the doses to skip the morning to no avail. The doctor kept referring to the cysteine as the cause of nausea so that's a new thought that it could have been the L-dopa instead. That would make it worth another try. I am on the road and so I don't have his lab tests or dosages, but I will look for them when I return. As I recall, he had sky high serotonin and extremely low norepinephrine. I'm not sure if I'm recalling the dopamine results correctly, but I believe it was in the high but normal range and then went too high on subsequent tests. I will post more information soon. THANK YOU!!

Yeah knowing what dosage he was on would be really helpful for identifying the problem. If it is the L-cysteine that is causing problems, which is very rare, you can switch to taking L-Methionine at 5,500 mg a day instead of the 4,500 mg of L-cysteine. I would only do this after consulting with a doctor who talks with Dr. Hinz first though. From what you have written on your doctors response to what has happened so far, I am worried that the doctor you were working with does not know what they are doing. With identifying a significant clinical symptom like nausea, there should be an immediate work-up done to identify the cause of the problem and then a solution should be rather easy to manage. For instance if it is the Cysteine then switching to Methionine. If he is taking a significant amount of L-dopa then manipulating the 5-htp to control nausea, etc. Also, you state that the serotonin was extremely high and the norepinephrine was low, which is not really how these things work. A high number on the tests can actually signify very low concentrations in the brain depending on if it is phase 1 or phase 3. It is kinda complicated, they detail it more in their peer-reviewed papers. Also, until the patients symptoms are stabilized you should not be getting lab tests on norepinephrine, it should only be serotonin and dopamine as the norepinephrine numbers do not matter until the serotonin and dopamine levels are optimized in the phase 3 therapeutic range. The fact that your doctor did not understand this is troubling.

Once you get back and can let me know what dosage he was on it should really help to identify the problem. Also, if you want to continue on with this program, I would highly suggest switching doctors. It is essentially impossible to successfully do this with a doctor who does not understand how to interpret the lab tests or know what to do when a problem occurs. I personally work with a doctor over the phone, who I can vouch for actually knowing what he is doing. I can link you up with him if you like. It simply won't work if you don't have a doctor who has the experience needed. Also, if he just has depression and anxiety, those diseases are usually pretty quick and easy to manage. If you worked with this doctor and did everything correctly he could likely be optimized within a few months.

Here are a few links that detail how to manage side effects: https://neurosupport.files.wordpress...de_effects.pdf https://neurosupport.files.wordpress...sexpanded1.pdf

I can't thank you enough for the insight you've given. We went with a doctor by phone in California and you are right, he didn't know a lot of what you are sharing here. May I ask which doctor you are working with? Thank you for all of the info and I will look for our lab and dosage paperwork.

well said I think billbobby21, for me at least.....but I cant find a doc across the US that knows the ins and outs of L-Methionine and 5HTP........in my limited experience an individual must figure this pharmacological conundrum out on their own (or with help from folk like yourself) in order to properly implement the L-Methionine/5HTP etc......I would get a look from my doc at least like....."who the hell are you and what do you know of pharmacology/o-chem/biosynthesis pathways" like for example the Krebs Cycle.......ask your doc how many NADH's it takes to make one ATP.......he has no clue.......until he googles (if your lucky)......."the role of NADH in the production of adenosine tri phosphate as a product of the citric acid cycle"............they don't remember/know............you need a seriously savvy doc....not neuro......not specialized enough......at the least a movement disorder specialist as part of a team working in tandem with Psychoanalysts, Primary Care, neuro, and homeopath/nutritionist...........most of us cant put together a competent team like that god knows ive tried from Colorado to Alaska........I wish you luck hangon and advise that you study the pharmokinetics of amino acid chains and how to best "interject" this info. into your regime. just my .25 cents worth......a year or more study time for the patient/caregiver.........of course I may be underrating the tenacity/knowledge base of the layman/laywoman...........and plead ignorance to the extent at which hangon is into pharmokinetics/pharmodynamics. If your well versed in such subjects than PD Alchemy is not unjustified in this situation.......research/implement/observe/adjust.......tell your quack.....sorry ...."doc".....what you are going to do and why and let the ducks fight it out amongst themselves as they look for loopholes in the Hippocratic oath.....which is taking on the appearance of swiss cheese....baby swiss.....lots of holes! at our expense.....Literally......

(don't crucify me hehehehe)

peace,
BP

For example....the "quick and easy" management of my anxiety from the specialists was......clonazepam at night, 1 PO,........temazepam HS 1 PO,...... alprazolam, TID......I was addicted and strung out in 1 year (dosages don't matter I was at MED on all 3....minimum effective dose)...to come off clonazepam etc I used a razor blade to shave off ever lessening dosages just to titrate down to a point where I didn't pee myself every night....can you say......COMATOSE.......or EXCESSIVE SOMNOLENCE.......whew! what a bunch of pill pushers......damn near killed me......used the same razor on heromet and the additional barbs.......took at least 2 years to come off that crap......now I have a nice clean mattress! hahahahahaha...no kidding.....the words "quick" and "easy".....are addiction red flags in my world.......but I live in a world of my own and don't mean to step on the toes of the obviously intelligent/well researched billbobby..........who obviously understands the pharmokinetics of these things....also....if you plan to tackle things with antidepressants stay away from at least the tricyclic's.....pure poison and shown to "cause harm".....theres hat dang Hippo oath again! and all this was TEAM APPROVED....not just outliers on the spectrum....University of Colorado Hospital to be precise.......and Co Dept of Mental Health et al et al........

peace
BP