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07-29-2016, 02:40 PM
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07-29-2016, 02:41 PM
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Modulating global DNA methylation -- either by injecting methionine to increase methylation or applying RG-108, an inhibitor of methylation, to the striatum -- modified the dyskinetic behavior of LID, down or up, respectively.
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08-11-2016, 09:03 AM
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08-12-2016, 02:10 AM
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The article from ScienceDaily says:
"The treatments we have used here, methionine supplementation or RG-108, are not practical for human use; but they point to the opportunity to develop methylation-based epigenetic therapeutics in Parkinson's disease." The message I get from the article is that a new research direction has been established in the battle with LID, but it will be quite a few years before PwPs can expect a new drug to become available (if ever). |
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