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Old 06-12-2016, 09:41 AM #11
LisaAnnB LisaAnnB is offline
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Here is a post from Consumerlab... that some supplement makers may put "more" vitamin in a product..

I have been having neurological symptoms, and a blood test showed I have toxic levels of vitamin B-6. My multivitamin contains 75 mg of B-6, but this is below the upper limit of 100 mg per day. Could my vitamin contain more than it lists? Answered by

This link explains the steps to do to provide an accurate result. Notice the hemolysis as a condition to reject the sample.
Hemolysis occurs when a butterfly needle is used also.
What it means is that the cells in the blood burst and flood the serum with the B6...giving a false elevation. (this commonly also leads to false potassium elevations also).
Vitamin B6 , Plasma (926)

I am still looking for the actual lab procedures... calibration of the machines,etc...but I am having trouble finding it. When I do I will add to this post.

This link explains how high B6 levels in testing occur in people not taking high B6 supplements.
This seems to be related to the MTHFR mutation:

The Cause of Vitamin B6 Toxicity is Not What You Think


MTHFR genetic errors are being found today in up to 30% or more of people tested.
And I don't know how to upload files on here or anything or I would. This doctor from Mayo just put out a warning on his page though. It's becoming more and more common.


Gutierrez Holistic Family Medicine
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Old 06-12-2016, 09:46 AM #12
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And I don't know how to upload files on here or anything or I would. This doctor from Mayo just put out a warning on his page though. It's becoming more and more common.


Gutierrez Holistic Family Medicine
Are You Overdosing On Vitamin B6?!
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Old 06-12-2016, 10:02 AM #13
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Please notice this quote from that website of the doctor's....
Quote:
If you are experiencing a deterioration in your health and you are taking megadoses of vitamin B6 follow up with your doctor immediately.
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Old 06-12-2016, 10:09 AM #14
LisaAnnB LisaAnnB is offline
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Please notice this quote from that website of the doctor's....
I don't understand your point. He also states that no one should take more than 25mg including all food sources because it will damage your health and that changes are evident within a week or two of taking it.
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Old 06-12-2016, 10:11 AM #15
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Please notice this quote from that website of the doctor's....
You are considering megadoses to be 400mg. He is considering them to be anything over 25mg
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Old 06-12-2016, 10:28 AM #16
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My point is that one cannot make sweeping statements about this topic. People vary genetically and some have even been born with infantile spasms and require high B6 therapy for life.

Also those with pyroluria or who take medications known to deplete B6 would have different requirements for it, than those without.
The general families of drugs that are known to deplete B6 are:
estrogens (HRT and birth control pills)
most antibiotics
loop diuretics
Estrogens and the diuretics are most often given long term, but some antibiotic treatments can be long term also (lyme or PANDAs).

This article shows some evaluations for 3 nutrients that often can become toxic depending on dosing.
pyridoxine
niacin
selenium

Toxicology of Micronutrients: Adverse Effects and Uncertainty

One should always question high reported lab results, and have a retest and control handling of the specimen. Labs make errors all the time.

I think the deficiency of B6 is much more common that toxicity issues. Using a keyword of "toxicity of pyridoxine" in PubMed was not very fruitful today.
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Old 06-12-2016, 10:38 AM #17
LisaAnnB LisaAnnB is offline
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Originally Posted by mrsD View Post
My point is that one cannot make sweeping statements about this topic. People vary genetically and some have even been born with infantile spasms and require high B6 therapy for life.

Also those with pyroluria or who take medications known to deplete B6 would have different requirements for it, than those without.
The general families of drugs that are known to deplete B6 are:
estrogens (HRT and birth control pills)
most antibiotics
loop diuretics
Estrogens and the diuretics are most often given long term, but some antibiotic treatments can be long term also (lyme or PANDAs).

This article shows some evaluations for 3 nutrients that often can become toxic depending on dosing.
pyridoxine
niacin
selenium

Toxicology of Micronutrients: Adverse Effects and Uncertainty

One should always question high reported lab results, and have a retest and control handling of the specimen. Labs make errors all the time.

I think the deficiency of B6 is much more common that toxicity issues. Using a keyword of "toxicity of pyridoxine" in PubMed was not very fruitful today.

That's because there are hardly any studies on it. That is my point. There was a recent study done in London a neuros office. She was looking for b6 deficiency in her neuro patients. She was shocked to see that out of like 300 patients, 4 had low serum levels, something like 130 had high serum levels and were toxic. She questioned the patients and they were all supplementing. Her conclusion was that many neuro patients have high levels of b6 due to supplementation and that neurological issues are an increasing problem in those who supplement with it.

Yes, people are different but b6 deficiency is not that common and studies have also proven that a vitamin with a normal daily value of 2mg increases serum levels just as quickly as 100mg and so there is no reason to supplement with such large doses.

In addition, even people with pyroluria end up toxic on it. There are numerous members on the b6 board who listened to some naturopath and started taking 100 or 200mg b6 and now have neuropathy which I can guarantee they would trade back for their anxiety or whatever pyroluria claims to cause.

This wasn't meant to be a debate. It was meant to be a warning. Many do not know that b6, even in small doses, can cause neurotoxicity. It needs to be known.
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Old 07-21-2016, 10:31 AM #18
Itneverends Itneverends is offline
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I am so tired of seeing a new person everyday on the b6 boards who has been poisoned by their doctors with the advice of supplementation of b6. It is a toxic vitamin. Some can take it and don't get nervous system
Abnormalities, but many many do! Even small amounts of b6 can be toxic. It is not normal to have elevated b6 levels when supplementing. It means you are toxic. This stupid vitamin keeps ruining lives on a daily basis and I don't understand why the word has not gotten out about it. Some become toxic within days, weeks, months of taking it. It will cause PN in many people, a severe PN. People, please check your supplements. This is one not to mess with unless proven to have a severe deficiency. Eat an avocado.
Lisa Ann, are you better? I am 6 months into this and I am burning like crazy. I was toxic a very long time I suspect...yrs perhaps.
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