was taking interferon 1b (betaseron for about 12 years). Switched to Avonex to help with the awful injection site reactions. Been on that a couple years now.
Now I am developing Onychloyosis which is where your fingernails separate from the nail bed. During this same time period, I've also developed Duphrens Contracture which is basically a thickening of the ligaments in my hand which may cause my pinky and ring finger to bend toward the palm.

I am really wondering if this has anything to do with my m.s. meds. Ive been to 2 dermatologists who don't think so....Nuero doesn't think so either.

I'm at a loss and docs can't seem to find whats going on with my fingernails.
No fungus and my toe nails are fine

This nail problem is often a sign of Lupus.

I am sorry I can't address your question directly, though.

I just had my right big toe nail separate partially for no reason and it bled like crazy. Took two weeks to settle it down. I almost went to my podiatrist (who would have removed it). I had the left
separate completely two years ago after a little bump... he removed that one, and a weak icky nail grew back. I have some mild form of lupus, that was triggered by a medication, lisinopril.

I'd call the doctor, as they might want to test your ANA levels etc.
There are drugs that induce lupus... but I don't recall seeing Avonex on the lists. That type is called "drug induced lupus".
Candida infections on nails can cause them to separate off the nail bed too.

The ligament contracture you describe is mostly hereditary as far as I know, and there is a surgery you can have done by a hand specialist to release the tendons.

Thanks Mrs D., for the quick reply. I will look into getting my ANA tested.
I don't have any other symptoms of Lupus, but my docs were concerned about Lupus when they found the M.S.
I have read that the ligament problem and onychlyosis of the nails can be from liver damage, but my tests are always ok.
I just had a surgery for a rare disorder called Eagles Syndrome. Super rare, but its where the styloid bone at the base of skull calcifies and grows and ends up poking the area in the throat where the tonsils are. Caused me neck and ear pain and a feeling like something was in my throat.
I'm in Michigan but had to go to Chicago for the surgery. I was concerned about all these things popping up at once.
Autoimmune diseases run heavy in my family.
I've been reading a book on autoimmune diseases that say all autoimmune diseases have one thing in common...a missing enzyme that screws up the protein floating in the blood stream. Diet can help. Its kinda a tough read, but I just keep going back to the information. The book is called: AUTOIMMUNE THE CAUSE AND THE CURE. By Brockley and Urdiales.
I would like to stop thinking about all this stuff for awhile, but the new conditions have me searching the internet again! Ugh.