Yes, I am on Rebif and if I don't take an advil at the time I do my shot each night, I will wake up a few hours later either drenched in sweat and burning up, or shaking with chills that can't be fixed with 3 extra blankets on the bed. If I remeber to take the advil, I have no problems and never notice any hot or cold symptoms, but if I don't, I get one or the other every time. FWIW, I only take a single advil, not the full dose of 2 and it seems to work for me.