in aug 04 when husband first diagnosed, neurologist,MDS he consulted recommended coq10@1200 mgm/day. there was noticeable difference within one week of taking coq1`0 at this dose--less stooped posture, less "frozen" facial expression, recovery of his sense of humor. husband also reported "feeling better" and less fatigue. It may be comparing apples to oranges since we feel my husband's PD is related to his having taken a lipophilic statin, lipitor. statins deplete the body of endogenous coq10, so in his case, supplementing with it was an attempt to replenish the body's stores of coq10.
on the other hand, there are many studies showing lowered coq10 levels in platelets and serum in all patients with PD--these results and the theory that PD was the result of mitochondrial dysfunction were what prompted Drs. Beal and shults to undertake the coq10 study reported in 2002.