I had bad side effects from Rebif so when I came off of it I did not feel worse. But then I started Copaxone right away and that is what I am currently taken and have for over five years total. Rebif is a very strong interferon and I had worsening depression and terrible anxiety while on it for five months. But for some people it works great, go figure!

If your doctor thinks Copaxone would work for you, and you could manage a daily shot, and rotate injection sites carefully, you might consider it because it has the longest safety track record and with the least side effects. They are coming out with a new version sometime this year that is only taken three days a week as well, and I will be first on that list when it is available.