Hi Lin,

I have suffered from severe leg and upper arm fasciculations (muscle twitches/cramps) which were VERY painful - a couple of times since I have been taking mestinon for MG.

Both times, I was very ill with viruses, and took mestinon too soon. I usually take 60 mg every 3-4 hours, and (I think) - I took it about 2 hours apart - each time. I was so ill those times that I just could not remember when I had taken my last dose. I was weak - didn't know if I was weak from the virus or weak from MG and needed mestinon.

OMG - horrible pain. And very unsettling to my body.

Now, when I am very ill, (other than routine MG/chronic illness symptoms) - I make notations as to when I have taken my mestinon.

Your muscle pains may be a different type, but if you take mestinon, you might look at the time span between doses.

Remember, we are all different. We generally learn to understand our bodies, and just "know" when mestinon is needed, using the RX as a general guideline.

Take care.