I have had chronic constipation for 20 years largely because of anti- depressants which then set the chronic problem in motion (no pun intended!).

What has worked for me is Magnesium every night (which gets my colon moving) and the Vitamin D (oil in capsules works like Colace as a stool softener). Ironically, it wasn't until I got diagnosed with MS 6 years ago and then started taking vitamin D and magnesium that the problem mostly went away! If i forget the Magnesium I notice!

Pre- MS I struggled and had to use enemas a lot. I found that Probiotics helped more than anything else besides laxative drugs which I worried about getting addicted to.