I started taking Topamax a couple months ago for Meralgia Paresthetica. I have experienced memory problems, I am always thirsty, soda is flat, and get tired. My appetite has decreased and I have lost some weight . The memory problems are the most challenging, but I'm finding most of the time I can deal with that. I can't tell you how many times I have driven past my own street. I am the post it note queen at work. I have them all over my desk with notes, names, phone numbers, reminders, etc... But the Topamax has helped tremendously and I am willing to put up with the symptoms!