My Doctor changed me from Prozac to Wellbutrin, partly because I didn't feel prozac was helping me, and also to help me lose the weight I gained taking Lyrica (wow...works great!) I haven't had a big pain change, but am happier on Wellbutrin absolutely. I had a dreadful time stopping lyrica, took months of tapering. Stupid me, I switched from Prozac to Wellbutrin with no taper (I thought that they were similar). I thought my lyrica withdrawal symptoms had come back, but doing some reading realized that it was stopping Prozac after four years cold turkey. Not anywhere near as bad as lyrica, but still an issue, so I'm now doing short taper off prozac. Once again, my fault for not doing the research myself before taking action.