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Old 08-18-2013, 11:57 AM
Bogusia Bogusia is offline
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Join Date: May 2013
Location: Vancouver Is
Posts: 90
10 yr Member
Bogusia Bogusia is offline
Junior Member
 
Join Date: May 2013
Location: Vancouver Is
Posts: 90
10 yr Member
Default Tremor syndrome in dogs

This condition is afflicting certain breads of dogs and it looks like it has some similarities to PD. The use of prednisone to treat it is interesting as there were some reports in this forum on the use of prednisone by PD members.

"The generalized head and body tremors can range in severity from mild to incapacitating and tend to worsen with exercise, stress or excitement and lessen or resolve with sleep. Other neurologic signs (deficit in menace, nystagmus) may be present, but are not always noticed. Screening for infectious agents is generally negative. Cerebrospinal fluid analysis often reveals a mild lymphocytic pleocytosis, but may also be normal. Histologic exam of the CNS tissue of affected animals varies. A mild, non-suppurative meningoencephalitis with mild perivascular cuffing, most evident in the cerebellum, may be identified, but normal CNS tissue can also be found. The underlying disease process is still unknown. Some speculate that the tremors are due to an immune reaction targeted against the tyrosine producing cells. Tyrosine is important in the production of melanin as well as the neurotransmitters dopamine and norepinephrine. An imbalance of these neurotransmitters may lead to the clinical signs observed; however, variation in the pathologic changes identified in tissues suggests that inflammation is not the only mechanism involved in the pathogenesis. Diagnosing a white shaker dog is one of exclusion and response to treatment. These dogs respond to an immunosuppressive dose of cortico-steroids (prednisone). "

https://www.addl.purdue.edu/newslett...ng/tremors.htm
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johnt (08-18-2013), RLSmi (08-19-2013)