Hi, TBI/PTSD
That is good that Latuda is helping you.
Are you taking it with 350 calories of food?
Most meds are absorbed better with food.
Latuda has it listed:
http://cpnp.org/resource/mhc/2012/12...-dos-and-donts
Quote:
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The newly approved 120 mg and 160 mg lurasidone dose is administered once daily, preferably in the evening with at least 350 calories of food in order to optimize bioavailability.4 Lurasidone is primarily metabolized in the liver through the CYP3A4 enzyme system, and coadministration with drugs that are strong inhibitors of CYP3A4 (e.g., ketoconazole) or strong inducers (e.g., rifampin) is contraindicated.4
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Also here:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171824/
Quote:
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Peak serum concentrations (Cmax) and absorption occur in approximately one to three hours. From 9% to 19% of the administered dose is absorbed. Following administration of a 40-mg dose, the mean apparent volume of distribution is 6,173 (17.2) L. The drug is highly bound (approximately 99%) to serum proteins. According to the manufacturer, patients were instructed to take lurasidone with food (consisting of a minimum of 350 calories) in a clinical trial. The Cmax and area-under-the-curve (AUC) concentration of lurasidone, when consumed with food, were about three times and two times, respectively, the levels observed under fasting conditions.15
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I used to get copies of the DSM. When my nurse friend would get a new DSM, she would give me her old copy. I gained a lot by looking through the manual, not only for my meds but other meds as well.
Mari