Thanks for posting the link.
In my opinion, alpha-synuclein's key role in the etiology of PD is as good as proven, although the details remain:
- what causes the misfolding to start?
- when does an instance of misfolding become prion-like and "reproduce"?
- is a genetic predisposition to over express AS important?
- are rogue forms of AS communicable?
Clumping seems bad news, but in vitro tests [1] have shown that curcumin can reduce aggregation.
Tag johnt:alpha-synuclein
Reference:
[1] J Biol Chem. 2012 Mar 16;287(12):9193-9. doi: 10.1074/jbc.M111.325548. Epub 2012 Jan 20.
"Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate."
Ahmad B, Lapidus LJ.
http://www.ncbi.nlm.nih.gov/pubmed/22267729
John