Hi Vanessa, I've had MS for more than 20 years and most of my symptoms are mobility related. I do have what I consider cognitive fallout more and more now. Also, fatigue is a huge issue but I take naps often.

I haven't had any skin color changes that I'm aware of, but do have circulation issues. My doctor and I attribute that to my lack of mobility. I spend a good part of my day in my chair. Sometimes my feet turn blue and I have to manually "pump" my legs around to get them back to normal. Sometimes my left ankle swells way up (that leg is as good as dead weight).

There's another forum down a ways dedicated to MS, it might help to ask over there, too. Good luck with this, I'll be interested in seeing what is said by others.