Funny--my neurologist wanted me to go from 25 to 50, and I thought that would be too big a jump. (Of course the stuff is manufactured in 10, 25, and 50 mg. pills.) But I persuaded him to give me a script for one 25 and one 10 per night, and that's probably why I didn't have a problem tolerating the increase. By the way, another neurologist said she has people go to 75, but mine didn't think I'd get any more benefit at 75 than at 50. It's all trial and error. Anyway, best wishes for a low-pain day tomorrow!