The woman I know is also JC+...the MS center she goes to is infamous for pushing Tysabri-I know several people who go there, and they're all on it. A neighbor, who was recently dxd, is also on it and is also J+. I couldn't believe my ears...

IMHO no DMD is 100% safe. I was on Copaxone, and I look like the moon with so many craters. So it's a question of quality of life...you take your chances, hold your nose and jump in...