I've been searching the internet, and there is ample evidence EVERYWHERE that Suboxone/ Subutex (Buprenorphine) works wonders for Depression. I have been taking it on and off for a few years - I never take it more than a few times a month because if I take more than that, it doesn't work. Plus, I don't want to end up in an ER with a broken bone and pain medication doesn't work. But yes, I swear it's a conspiracy. I don't think pharmaceutical companies want people to know about this because they want you to stay hooked on their tranquilizers (Benzodiazepines) and anti Depressants (SSRIs, SNRIs) for life. If you kept a pill around for once in a great while, when you feel truly awful - or one you could take for a week and feel better for a few months, how much money would they or your doctor make off of you? Not much. So, these doctors will continue to dope us up with anti depressants and tranquilizers. I'm currently hooked on Klonopin (2.5 mg a day for 3 years) and Effexor (150 mg for nearly 2 years) and they don't help much at all. Bupe (Suboxone, or Subutex) helps every time, but I wouldn't take it every single day unless I was in horrible pain, or if I was suicidal without it. You will become addicted and then what's the point - you're in the same boat you were in when you took the other garbage the doctor gave you. BTW, I have never been as addicted to anything as I have Effexor (Venlafaxine, An SSRI - that's a serotonin/ norepinephrine reuptake inhibitor). I had TRD (Treatment Resistant Depression) and I swear I wish I never got hold of this horrible drug. THe side effects are killing my relationship (no sex life, whatsoever), and if I miss one dose, my head is in horrible pain, I'm dizzy, nauseous, and horribly depressed. This has been my experience. Your mileage may vary. However, as far as Buprenorphine goes, I have always found it to be a godsend - but as I said I wouldn't dare take it more than once in a great while. I do think the doctors are starting to prescribe it for Depression because - it works - but I doubt it would work for long if you're taking it every day for depression. You want that euphoria, and after about a week or so, that goes away. I'm very angry with the whole psychiatric profession (I still thank them for trying) for getting me hooked on anti-depressants and NEVER TELLING ME THEY ARE HORRIBLY ADDICTIVE. Anyway, Buprenorphine works. I believe there was a study (only 1) done on people who took low doses for a week, and the vast majority were greatly improved - however a week is only a week. I wouldn't want to take this long term, but I'm sure there are some who do. If you do, chime in. Please.