Hi all,

I normally post on the PN forum since I have PN and severe autonomic neuropathy. I come to you all today because I am being considered for treatment of my autonomic neuropathy with Mestinon...which of course is commonly used for MG.

Mestinon has been found to help with orthostatic hypotension, tachycardia, and gastroparesis...among other autonomic dysfunctions. My condition has become quite debilitating after 17 years and my current medications are just not always effective enough. So we're hoping the Mestinon will help improve the quality of my life.

My doctor has just decided to go ahead with a trail but insists that i have a doctor closer to me (the neuro is 3 hours away) for close monitoring due to side-effects. He even asked how far away the closest ER is from me. So now I'm a bit concerned about how serious the side-effects really are. At the first discussion he really didn't make a big deal of side-effects and said diarrhea was the most common. Well, certainly that's not why he asked about an ER or having another doctor to monitor.

So I'm here to ask you all what is the most problematic side-effects and what else I should be aware of? Any and all input would be helpful.

Thanks in advance.