Howdyyy!
I haven't been here for most of the summer because I was having too much fun. It's still warm here, 70s this week so I have to suck up the heat before it gets cold and dark and I have to hibernate!

Good to see everyone's doing well! I had infusion # whatever in Sept, and have two in October, I'm moving backwards! Everything's going well, no problems or concerns as usual.

Natalie, thanks for the PML article you posted. Very interesting to see that they are finally examining the dosage and body size in reference to PML. I always said it mattered and it's nice to have some evidence based study to back it up!
"Different weight based doses were tested in the Natalizumab Phase 2 trials and it was decided that the effect of patient weight on clearance was within typical inter-patient range and so wasn't clinically relevant..." http://www.ncbi.nlm.nih.gov/pmc/arti...MC1936307/#b39 but that was before PML reared it's ugly head. The difference in two people IS clinically relevant ( like when you and I stand side by side eh? ) when it comes to how long it takes to clear any drug and how high the concentration of any drug is in our bodies.
Good site too, I got lost reading there! I liked this study too! http://www.clinicalneurologynews.com...012b44d00.html

Hey Sal? No rafting lately but I was out in my canoe today, checking out the bottom of the lake. The water is being lowered so the dam at the end of the lake can be worked on (some drunk crashed and dislodged the dam) and I was out on glass smooth water searching for treasure!