Interesting. Both my GP and neuro are still "fans" of amitriptyline. It's and oldie, and has been well studied. As an anti-depressant, it is just as effective as the newer medication, but apparently it's less used now because it's hard to treat (deliberate) overdoses.

I did try it for the pain and built up from 10mg to 50mg over a period of five weeks (as prescribed). I do not recall any side effects, but it also didn't help the PN (which was the reason I took it) so I went back down to 0 in 5 weeks, again with no ill effects.

I must say I'm a very good sleeper (for which I am very thankful, it's a life saver), but I can immediately see why sleeping better could make you feel less "grumpy".

As for Lyme, it shows again that medicine can have a strong regional component. For me, it was the absolute first thing they tested (both ELISA and WB), as Lyme is very common where I live; however, move 50km to any direction, and they probably wouldn't even think about Lyme.

Both tests were negative, and as I had come clean about my alcohol abuse, they didn't look any further (and they were probably right. )