Rsd is different for each person on how they and it reacts to different situations. If she had an exam by a drnthatnisnt familiar with rsd and he actually did something to cause a flare its hard to prove but it also has bad consequences for us. I personally am just now having mine spread from just my knee to all the way down to my foot and half way up my thigh. Its been almost 10 yrs that Ivemhad this too. If her meds aren't helping by all means get her to the ER. It might also be that her meds aren't working as effectively as they were. You can build up a very high tolerance for a med. I would have to take a half bottle of the strongest tylenol to get it to work and that would be for only about 20 min.