Quote:
Originally Posted by RSD RENEE
SECOND STUDY CONCERNING MITOCHONDRIAL DNA AND CRPS TYPE 1
Furthermore, in a second study, this one also done at Children's Hospital in Los Angelas by Drs Higashimoto, Boles, Baldwin, and Gold. Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance.
I found the following conclusion was drawn;
CONCLUSION:
In one tertiary-care paediatric genetics practice, children meeting the CRPS-I diagnostic criteria frequently had additional autonomic-related conditions secondary to maternally inherited mitochondrial disease, suggesting that mitochondrial DNA sequence variants can predispose children towards the development of CRPS-I and other dysautonomias. CRPS-I should be considered in patients with mitochondrial disease who complain of idiopathic pain. Maternally inherited mitochondrial disease may not be a rare cause of CRPS-I, especially in children who present with other manifestations of dysautonomia.
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Very interesting Renee, thanks for posting this. I'm a scientist, but not a medical one lol - however I do understand some of the cell level genetics, and it would certainly make a lot of sense for there to be a DNA connection - I particularly note the term 'may predispose' - ie just because you have the damaged mtDNA doesn't mean you WILL develop CRPS or another condition, just that you are more likely....
Maybe for us rare few
, we have that Bermuda Triangle effect going on - where all the fates have aligned (the damaged DNA, plus the injury/surgery, plus some other unknown factor) but in a bad way, and CRPS is the result for us.
I just hope (oh crumbs I really hope) that this kind of research and thinking will one day result in the development of a treatment that actually WORKS specifically for CRPS. It is a dream we all share!
There are so many if's in our lives. I often wish I'd never let that darn surgeon 'just have a look around' in my knee....but maybe I'd have ended up with it anyway from something else? Who knows.
Take care all,
Bram
