H Jen - Mestinon does have some side affects for some people. They are generally not permanent, but they can be uncomfortable for a few hours. For me, if I take it closer than 3.5 hours apart, it affects my GI tract with horrible cramping and diarrhea. If I keep it about 60 mg every 3.5 to 4 hours, I don't have those problem. However, as with everything else with this disease, it is different for everyone. I do use the 180 Timespan at night and if I somehow forget it (senior moment!), I really notice it the next morning. I can hardly get out of bed and will delay my shower until my morning mestinon takes affect.

Good luck with finding what works best for you!

Juanita