'The Electronic Textbook of Dermatology' at
http://telemedicine.org/stamford.htm
Read the parts about 'diabetes in skin disease' it explains the inter-relationships between the neurological, vascular and lymphatic systems. Seems a lot can go wrong.
While I've a Sensory PN due to CIDP...it's demeyelinating, tho at the ends, not the brain. How those faulty nerve signals go to the brain and back, thus telling the other systems to work [or NOT, in our cases], this site has explained a LOT....least to me.
This kind of information constantly amazes me in teaching me that in many ways we ARE delicate creatures/mechanisms or whatever. WE are more fussy than our computers! And, much of how we are diagnosed and then treated is thru so much trial and error. Every day is really a gift, even tho it can hurt.