Hi Clarkstar,

I have little experience with the heavy hitter meds, as I am sort of looking down a similar road as you at this point; but others here do so hopefully they'll chime in.

You might consider adding LDN to the mix. It is not a cure, does not make Sxs magically go away, or anything super specific along those lines.
What it has done for me and some others, is take the edge off of some of the Sxs, and sometimes that can make all the difference.

I've been on it for over a year and know that if I go off of it (have done so a couple of times), that within two days I feel like I am in a flare and that it takes another 3 or 4 days to get "normal" again.

Wishing that you find something that works for your situation.

With love, Erika