Sounds like you have a good and proactive doc. Get ready, because the steroids can make you feel like crap all on their own. But they should help with the other problems by the time you finish them. As for the meds, I don't know much about tecfidera, but I was on Copaxone for several years. I had a good experience with it and didn't want to change, but I had an MRI show more lesions showing up, so doc recommended changing to Rebif. I have been fine on Rebif other than hating the fever and chills I get if I forget to take an advil with it.

One thing to note however is that most insurance companies are changing the way they treat Rebif because it is very expensive, even relative to the other MS meds that are expensive by themselves. My insurance company (United) is not only charging a 20% copay this year (which is common for most of the biological meds for MS), starting January 1st, they are making Rebif a tier 3 biological, which for me means a 25% copay, AND they won't accept direct payment using the manufacturer's copay assistance program. So I will be paying approximately $1125 out of pocket each month next year and then submitting that to the copay assistance program for reimbursement. The moral of my long-winded whining is that before you choose a med to try, make sure you understand how your insurance company classifies it and what they will charge you for a copay. Also be aware that most of the manufacturers do have a copay assistance program to help if you can't afford it. I hate the idea of making healthcare decisions based on some arbitrary cost guidelines from an insurance company, but it is what it is. FWIW, United is not treating Copaxone, Avonex, or Betaseron the same way...just Rebif for some reason.