--from my knowledge; you do seem to have some sort of systemic neuropathy (so I don't think it's just "typical" carpal tunnel).

Without getting into incredible amounts of jargon, the results you reported over all seem to imply mostly demyelination of nerves, with possibly some secondary axonal deterioration. For the "large fiber" nerves--all nerves to muscle, and those sensory nerves that monitor position, vibrational, and mechanical touch--a series of fatty coverings, the myelin, covers the nerve fiber, or axon, and helps to conduct impulses down it. Slowed conduction times imply a deterioration of the myelin "insulation".

The "small fiber" nerves, autonomic ones and those sensory nerves that subsume the sensations of pain and temperature, might also be affected but they cannot be tested by nerve conduction studies or EMG as they are just too thin to isolate.

There are numerous causes of demyelinating neuropathies:

http://neuromuscular.wustl.edu/nother/myelin.html

You say you've had an extensive lab work-up, but in my experience unless it's been at a tertiary center or a neuropathy center of excellence, where research is also done, it probably hasn't been extensive enough, particularly in regard to possible autoantibody testing.

Take a look at :


www.lizajane.org

http://www.questdiagnostics.com/test...ripheralNeurop