Originally Posted by limpy

Mestinon usually starts working within an hour. It is a short acting drug so wears off in a few hours. When I first started taking it I had those same side effects. They should settle down as your body adjusts. If not, you may have to take a smaller dose and take it more often in order to get the benefit without the side effects. I cannot tolerate more than thirty mg at once, just need to take it every two hours.