I have suffered for several years with pain that starts in the groin and radiates down to the knee. It can be one or both legs, sometime the right only or the left, there is no pattern. Rarely it can go from the knee to the ankle. I have tried Lyrica, Lortab, Advil, nothing works. A heating pad offers some relief but, the only thing that helps completely are nerve blocks. They last 3 months or longer. Do your homework to make sure its for you but, if your pain is unbearable like mine, it will be a blessing! Im still not sure exactly what causes my pain but, the block stops the nerve signals to your brain. I couldn't live without them. Hope this helps!!