It all depends on what is the cause of the damage. Diabetes is one common offender. In this case, it's possible to reduce symptoms by controlling your blood sugar.

Other causes, such as autoimmune disease is not so easy to fix. If AI disease like Sjogren's has attacked the ganglia, then damage is usually permanent and your best bet is to control the progression of the AI disease and therefore slow or stop progression of the nerve damage.

Some people here have reported reduced symptoms from toxic type dysautonomia from use of benfotiamine. Your B12 level should also be above 400.

If you don't know the cause, it certainly can't hurt to try various supplements. There are also several medications for POTS to help control heart rate and BP and reduce symptoms.