Experiment to see if ibuprofen (200mg) relieves my bradykinesia.

As Rick points out, most of the research into whether ibuprofen impacts on PD relates to the negative correlation between ibuprofen usage and the relative risk of getting PD.

As far as I know, whether ibuprofen has an immediate effect on PD symptoms is unknown. This is what we look at here.

I've never taken ibuprofen as part of my Parkinson's medication. But, I have taken it, infrequently, when I've had headaches. On some of these occasions it has seemed to slightly relieve my PD symptoms. Of course this is just a subjective opinion.

To get objective data, I took the tap test [1] every 10 minutes starting 40 minutes before taking 200 mg ibuprofen and continuing until 160 minutes after taking the pill. To get control data I needed a time when my performance was stable, so I started 3 hours after last eating and 32 hours after my last medication. During the test I neither ate nor drunk (except for a little water to get the pill down).

The raw data is shown below.

I cannot see any evidence of an improvement of motor performance.

The next step is to test whether ibuprofen taken with levodopa has better performance than levodopa taken on its own.

Reference

[1] http://www.parkinsonsmeasurement.org...eToSideTap.htm

John

The data is in the format:
Min: minutes relative to taking dose. Negative value refer to the time before the dose
LH: left hand score, 30 sec
RH: right hand score, 30 sec

Min , LH , RH
-40 , 18.20, 12.81
-30 , 17.94, 12.92
-20 , 16.91, 13.65
-10 , 18.00, 12.83
0 , 16.52, 13.58
10 , 17.19, 12.56
20 , 17.39, 12.36
30 , 17.26, 12.34
40 , 18.00, 12.98
50 , 18.36, 13.21
60 , 17.31, 12.73
70 , 17.59, 11.70
80 , 18.69, 13.67
90 , 19.40, 12.51
100 , 18.64, 13.45
110 , 18.70, 13.98
120 , 20.33, 13.53
130 , 19.44, 12.60
140 , 17.70, 13.44
150 , 15.71, 11.48
160 , 16.42, 12.48