Some of the compounded creams with several drug ingredients include clonidine.

The transdermal versions of this will deliver clonidine into the blood as well, and therefore it may affect blood pressure.

Clonidine has been used for many years in RSD patients whose neuropathy is slightly different from PNers. There are patch formulations that have been tried in RSD patients in the past.

I don't see clonidine mentioned as often on RSD today, but some of them may still have this ingredient in their compounded various transdermal creams.

The article is interesting though, but supervision and close attention to systemic clonidine actions must be maintained. Clonidine is not often used for blood pressure today as in the "olden" days...basically because of compliance risks. If it is discontinued suddenly there can be a huge blood pressure rise/spike, as a withdrawal event. This can be dangerous in some people (burst a hidden aneurysm or cause a stroke).

For example, the clonidine patch on the market today delivers .1mg of drug transdermally per day. That is a very small amount.

.1% as in the article would deliver, that same amount or more depending on area covered/amount used per dose. I suspect "more" would be the rule. It would be dicey to use this therapeutically....this article only mentions "diagnostic tool" use.

Time will tell if this progresses to clinical applications long term.

Thanks for posting it, however.