St John's Wort increases serotonin without regard for how much you need. L-Tryptophan helps your brain properly produce and regulate serotonin. L-Tryptophan is better and safer than St John's Wort. Plus, it is impossible to properly measure the dosage of St John's Wort .

Stay away from St John's Wort.

Get started with a B-12 (methycobalamin) two or three times a day. How about the rest of the regimen ? You need the D3 and anti-oxidants. B-Complex is just for the minor amounts of B's other than the B-12 and B-6. There is not enough B-12 in a B-Complex to make a difference.