I have learned that Vitamin D is low in most autoimmune disorders and therefore getting heaps of notice now. When I go to my endo for my Graves (autoimmune thyroid) my Vit D is always checked.

I am not certain that getting Vitamin D from a tablet/capsule and getting it directly from the sun is equivalent in terms of goodness or synthesized the same way in the body. I have also read that Vitamin D is actually not a vitamin but a neurohormone. When I went to Europe this past July, I had almost 8 weeks of full on sunshine many hours a day and my numbness/tingling completely went away. When I came back home (winter in Oz) numbness returned within first 5 days.

In terms of the M immunoglobulan being elevated, it can mean something (autoimmune,infection) or nothing really. Blood tests should be repeated periodically and clinical signs/symptoms evaluated together to paint a whole picture for your doctors. I have had positive ANA tests myself only to repeat and they are negative.

In terms of nerves I learned that even when the problem is corrected it can take a long time for nerves to settle down and or heal. Nerve tissue is very delicate and repairing it is a very slow process.

If I were in your situation with numb hands that were bothering me I would look to make sure I did not have nerve compression (carpal tunnel) as that is getting more common. My dad had to have his hands operated on because they were numb all the time. Then I would look into PT for my hands. I would increase my B12 & D, and take a good multivitamin. I would also look at food allergies/sensitivities and other vitamin deficiencies, and repeat my blood tests also checking for thyroid. I never thought that I had thyroid issues and totally believed my old GP when he said to me 9 years ago my thyroid tested fine. It turned out I had been hypothyroid for probably a few years which turned into Graves Disease in 2009. I only found out about the Graves because I had lost so much weight,sweating, and all my hair was falling out, so they ran a complete thyroid panel. If this was the cause or contributing factor to my neuropathy, since thyroid hormones are at cellular level, it will be a lifetime of maintenance. I try not worry about things that may never happen anymore. The stress of worry is more detrimental in the short term than the PN in many instances (such as with me).

Also pain is almost always worse at night. I have read countless threads where people say that the PN is worse at night. This happens for a few reasons that I know of. First, other distractions ar usually gone and brain can then focus solely on pain. Anxieties & fears are worse at night. Also sometimes air quality/pressure changes in the evening and this can affect peoples pain levels.
I hope I helped a little bit, I truly wish you luck.

Aussie