and can not find any papers about zinc excess and neuropathy.
Here is an example:
http://ceramic-materials.com/cermat/education/291.html
Quote:
Chronic and Long-Term Effects :
Other than producing corneal and lens opacities after ocular zinc salt injury and anemia from zinc-induced copper deficiency, zinc toxicity does not result in any known chronic effects.
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Now, this incident may be very unique. Or a scam. Zinc also produces gastrointestinal side effects. And anemia. Anemia is not mentioned on that news story.
Could not find anything here either:
http://www.intox.org/databank/docume...lt/ukpid89.htm
and this:
Quote:
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Toxicity: Acute zinc toxicity is characterized by gastric distress, dizziness and nausea. Symptoms of chronic toxicity include gastric problems, decreased serum ceruloplasmin activity and hypocupremia, decreased lymphocyte stimulation to PHA and reduced HDL cholesterol. An emetic effect occurs at >150 mg Zn/day. Consumption of zinc supplements produces measurable cellular effects but the long term benefit/risk of zinc supplementation has yet to be determined.
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from
http://jn.nutrition.org/nutinfo/content/zinc.shtml
Arsenic DOES cause neuropathy however, and so do some other heavy metals. A contaminated batch perhaps? Poor manufacturing practices?
I tend to think that more likely....GSK has had severe manufacturing issues with Paxil CR (FDA intervention) and Citrucel bulk laxative.
Given that PN can be very idiopathic...there may be more to this story and the other ingredients in PolyGrip. I would like to see some documentation of this issue...I could not find any papers on PubMed for example.
Here is another link:
http://ods.od.nih.gov/factsheets/cc/zinc.html#risks
It states that 40mg daily of ELEMENTAL zinc is the upper tolerable limit. The word elemental is important here. Since zinc SALTS dilute the effect. i.e. there is usually a little bit of zinc with ALOT of salt (carrier molecules). Zinc tastes really BAD... affects the whole mouth. Try a Cold Eeze lozenge
http://www.coldeeze.com/clinical_info/safety.html and see how your mouth reacts! I just did one a couple of weeks ago for a severe sore throat, and I can tell you even with flavorings..the zinc was powerful and somewhat "nasty". It took a whole day to recover taste and normal mouth functions for me. But it did nip that nasty virus for me. So the trade off was worth it. If PolyGrip were so high in zinc, then
the perceptions of taste would be significant and noticeable, IMO. Notice also that PolyGrip was reformulated in 2006 to improve "taste"...this might be a change in the zinc concentration. (notice one of the media articles was from Feb 2006).
Zinc requires active transport in the small intestine for absorption. It is not well passively absorbed without "help". These are called ligands. Skin absorption may also occur, but over LARGE areas...for example the "butt creams" as we compound in nursing home providers, are used on the skin in large areas, for long periods of time. I have never seen a case of zinc toxicity from this use. I searched and searched buccal (mouth) absorption for zinc and minerals, and came up with nothing useful basically.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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