One can develop drug induced lupus from long term use of drugs.

There are now 40+ on the list. This includes old timers thought to be "safe"...like hydrochlorothiazide and the ACE inhibitor family for blood pressure. Lots of other drugs for blood pressure also.

It might mean that because so many people take blood pressure drugs, the pool of prospective reactions is higher for that group.
All of the ones on the lists are chemically different. With more time we might find that all drugs contain this potential, and I've seen some comments to that effect.

I myself had a drug induced lupus AND angioedema attack last Feb or so, life threatening from an ACE inhibitor lisinopril.
That is when I started looking up this risk.

http://www.nlm.nih.gov/medlineplus/e...cle/000446.htm

http://www.lupus.org/answers/entry/w...-induced-lupus

The lists vary depending on what site you visit. Some are very complete, others leave off some drugs especially if they are recently added.

You can try searches on PubMed... to find papers about drugs...
use the generic name + drug induced lupus.

This does not raise ANA panels and a special antibody has to be tested for instead. Many doctors don't know this. Lupus does not always cause the butterfly rash on the face, my skin reactions are on my forearms. And I still have the skin redness, which comes and goes now. (I discontinued the lisinopril--which I had been on for about 10 yrs last February.)

Anyone on long term medications therefore is at risk from any drug IMO.