This is fascinating... because I developed Erythema Nodosum while I was taking Topiramate and weening off it (I had an initial mild attack, and then a much worse lengthier attack that left me immobile practically). Lupus, ironically, was on my GP's radar. I tested negative, again, for Lupus, and have not since had a bout of E.N.

No professional has ever validated that my E.N. was the result of taking Topiramate, but I know it caused havoc in my body in other ways, and the E.N. stopped after I'd been off of the drug for a couple months.

Frightening, because I'd only been on it a few months.

To this day, my neuro, who prescribed it for migraine prevention, denies my cloudy (abnormally so) urine, low BP (80 over 50), extreme weight loss (I was skin and bones), and E.N. all over both legs to be at all related to being on Topiramate.

Thanks for the head's up mrsD, you're awesome.