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Old 01-16-2014, 10:32 AM
JoanieP JoanieP is offline
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Join Date: Dec 2013
Location: Punta Gorda,FL
Posts: 23
10 yr Member
JoanieP JoanieP is offline
Junior Member
 
Join Date: Dec 2013
Location: Punta Gorda,FL
Posts: 23
10 yr Member
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Quote:
Originally Posted by glenntaj View Post
--has done a lot of work to show that there are celiacs/gluten sensitives out there who are not genetically DQ2 or DQ8--in fact, many with presentation that are not initially gastrointestinal are DQ1:

http://pn.bmj.com/content/4/2/124.full.pdf+html (see the reference list as well)

http://jnnp.bmj.com/content/72/5/560.full

http://celiacdisease.about.com/od/ce.../g/Hla-Dq1.htm
"From you url jnnp.bmj.com/content/72/5/560.full I identify with a part of this:
“Isn't the neurological damage nutritional?”
Nutrient deficiencies (B12, folate, vitamin D, vitamin E) are rare in this neurological population. Given that two thirds of these patients have no enteropathy this is hardly surprising. The concept of the neurological manifestations being nutritional in origin is now outmoded. Intestinal mucosal damage in coeliac disease is the result of both humoral and T cell mediated inflammation. Such inflammation is not, however, confined to the gut, as activated HLA restricted gliadin specific T cells25 and antigliadin antibodies are found systemically. Antigliadin antibodies are also found in the CSF.26 Postmortem findings from two of our patients with gluten ataxia has shown perivascular cuffing with both CD4 and CD8 cells. This inflammation was primarily seen in the white matter of the cerebellum. There was also marked but patchy Purkinje cell loss. We have also found antibodies against Purkinje cells in patients with gluten ataxia. Our research suggests that IgG antigliadin antibodies cross react with epitopes on Purkinje cells from human cerebellum.27 Characterisation of the anti-Purkinje cell antibodies by immunoblotting may provide a useful marker for the diagnosis of gluten ataxia in a manner analogous to the use of antiendomysium antibodies as a marker for coeliac disease or the anti-Yo antibody in paraneoplastic cerebellar degeneration."

My biopsy states: "The inflammatory process includes many T-lymphocytes, focal clusters of B lymphocytes and nummerous HLA-DR-positive and rare S-100-positive histiocytes. immunohistochemitry for CD3,CD20, epithelial membrane antigen (EMA) also."

Quite a bit of information, hence the pathological statement of "The dural biopsy shows a chronic inflammation without specific pathological characteristics, such as granulomas or multinucleated giant cells. No acid fast bacteria are detected. The findings are not specific and require clinical correlation."

Hoping for a good correlation that will be helpful in my journey of CD.
Joanie
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