for me I noticed that the 2nd day I had some mild improvements... then the improvements went up from there, however, when I get meningitis I am stronger in some ways from the IVIG and weaker in others due to the toll the meningitis/IVIG does to my system. The biggest improvement for me is usually day 4 after IVIG.. and the BEST improvement was the 2nd round of IVIG (I got the first 3 days in the hospital and felt better... but then 3 weeks later got a maintenance dose and it was like WHAM all back to normal).. The dr's told me it takes some people a few rounds before they notice an improvement. GOOD LUCK!!! drink lots and lots of fluids!