I took it years ago. For about 2 yrs....we all did in this house.

A modest dose however. GLA is an intermediate player in the EFA chemistry, so if people are very low they may not have much of this either.

But once EFA status is repaired, I think you will make your own.

This link explains the GLA paradox:
http://en.wikipedia.org/wiki/Essenti...d_interactions

I really don't understand how in high amounts this works however, so I don't recommend it. I do know that once I was
rather "fixed" by the EFAs I was using, I bought a stronger GLA by necessity on vacation. It upset my GI tract considerably...so I realized I didn't need it anymore and stopped using it.

This chemistry is very very complex... so even if one understands some of it...that might do. Steroids, and NSAIDs skew this chemistry and block Cox-2. High insulin levels fuel inflammation, and that much we know.

Basically you need to REDUCE Omega-6's, and increase Omega=3's to a ratio of 3 to 6 being 1:5. GLA is an omega-6, but seems to have multiple duties, much like the paradox with Cox-2 cytokine prostacyclin which unlike other Cox-2cytokines is not inflammtory. This of course makes it more complicated in reality. The mechanism of Vioxx damage was it blocked Cox-2 so well, that prostacyclin could not be made in the kidney, and hence its vasodilating actions were gone, and people had heart attacks (constriction). So one cannot block ALL cox-2, and in the same way some GLA Omega-6 is helpful. Got that? It is very complicated.

This is my EFA thread on the vitamin forum...
http://neurotalk.psychcentral.com/thread6092.html

I just fixed a dead link in it...so there may be others too.
This thread started 8 yrs ago!